Water Binding Stabilizes Stacked Conformations of Ferrocene Containing Sheet-like Aromatic Oligoamides

While water clusters play an essential role in the stability of biological structures, their ability to stabilize synthetic oligomers is less understood. We have synthesized a heptameric sheet-like aromatic oligoamide foldamer with ferrocene as turn unit that shows strong interactions with water in the solid state and solution. The water binding limits the fluxional processes resulting from the flexible ferrocene unit, highlighting the importance of such interactions for conformational studies on this class of molecule.