Agents Which Modify Channels as Potential Treatments in Alcohol Withdrawal
1992
The genesis of alcohol physical dependence is usually viewed as a consequence of adaptive mechanisms within the central nervous system. In this scheme alcohol produces inhibitory effects on neurones by some mechanism and this evokes an opposing adaptation in these neurones. Removal of alcohol once neurones have adapted in this way exposes this adaptation which causes the hyperexcitability of the alcohol withdrawal syndrome.
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