A withdrawal syndrome (also called a discontinuation syndrome) is a set of symptoms occurring in discontinuation or dosage reduction of some types of medications and recreational drugs. The risk of a discontinuation syndrome occurring increases with dosage and length of use. A withdrawal syndrome (also called a discontinuation syndrome) is a set of symptoms occurring in discontinuation or dosage reduction of some types of medications and recreational drugs. The risk of a discontinuation syndrome occurring increases with dosage and length of use.