Discovery of DS-1971a, a Potent Selective NaV1.7 Inhibitor.

Tsuyoshi Shinozuka,Hiroyuki Kobayashi,Sayaka Suzuki,Kyosuke Tanaka,Narayan Karanjule,Noriyuki Hayashi,Toshifumi Tsuda,Eri Tokumaru,Masahiro Inoue,Kiyono Ueda,Hiroko Kimoto,Yuki Domon,Sakiko Takahashi,Kazufumi Kubota,Tomihisa Yokoyama,Akiko Shimizugawa,Ryuta Koishi,Chie Fujiwara,Daigo Asano,Tomoko Sakakura,Kiyoshi Takasuna,Yasuyuki Abe,Toshiyuki Watanabe,Yutaka Kitano

Discovery of DS-1971a, a Potent Selective NaV1.7 Inhibitor.

2020

A highly potent, selective NaV1.7 inhibitor, DS-1971a has been discovered. Exploration of the left-hand phenyl ring of sulfonamide derivatives (I and II) led to the discovery of novel series of cyc...

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Organic chemistry
Stereochemistry
Chemistry

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