Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex.
2009
Here it is shown that PRDM16, a zinc finger protein that controls the switch from myoblastic precursors to brown fat cells, works together with C/EBP-β and that expression of this transcriptional unit is sufficient to induce a fully functional brown fat program in naive fibroblasts. Transplantation of such fibroblasts into mice creates a brown fat pad that acts as a sink for glucose.
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