BIORESORPTION OF POROUS 3D-MATERIALS BASED ON CHITOSAN.

: 3D-materials with high porosity were prepared by the method of lyophilization of chitosan solution. In vivo investigation of the mechanism and resorption rate of the resulting material in the muscle tissue showed complete resorption occuring in 12 months after implantation in an animal. The formation of scar tissue was not observed; there was no change and damage of the surrounding tissue. Histological analysis showed that chitosan resorption occurred simultaneously with the formation of collagen fibers and blood vessels. This allows us to recommend such porous material based on chitosan as a matrix for tissue engineering.