Plasmonic thrombospondin-1, via cell surface CD47, rescues animals from hemorrhagic shock

Homogenized lung tissue Neutrophil Lymphocyte IL1 (pg/mL) IL6 (pg/mL) Injured lung 84 74 70 66 788 78 2217 969 Noninjured lung 6 2** 2 0.8** 273 78** 59 11** Injured lung MSC 18 17* 10 10* 546 125* 563 135** CONCLUSIONS: Lung contusion stimulates an inflammatory response evident by elevated lymphocyte and neutrophil counts and a significant increase in inflammatory markers including IL1beta and IL6. The addition of allogeneic MSCs abrogates this effect, suggesting that MSCs promote healing through an immunomodulatory effect.