In Vitro: Natural Compounds (Thymol, Carvacrol, Hesperidine, and Thymoquinone) Against Sars-Cov2 Strain Isolated from Egypt
2021
Background: The current pandemic of the coronavirus
disease-2019 (COVID-19) has badly affected our life during
the year 2020. SARS-CoV-2 is the primary causative agent of
the newly emerged pandemic. Natural flavonoids, Terpenoid
and Thymoquinone are tested against different viral and
host-cell protein targets. These natural compounds have a
good history in treating Hepatitis C Virus (HCV) and Human
Immunodeficiency Virus (HIV).
Methods: Molecular docking combined with cytotoxicity and
plaque reduction assay is used to test the natural compounds
against different viral (Spike, RdRp, and Mpro) and host-cell
(TMPRSS II, keap 1, and ACE2) targets.
Results: The results demonstrate the binding possibility of
the natural compounds (Thymol, Carvacrol, Hesperidine, and
Thymoquinone) to the viral main protease (Mpro). Some of
these natural compounds were approved to start clinical trail
from Egypt Center for Research and Regenerative Medicine
ECRRM IRB (Certificate No. IRB00012517)
Conclusion: Development of an effective anti-viral for SARSCoV-
2 could help to limit the viral load. Benchmarking testing
of those natural compounds against other potential antivirals
for SARS-CoV-2 with alternative mechanisms of action would
thus be important as soon as practicable.
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