Estrogen protects against β-amyloid-induced neurotoxicity in rat hippocampal neurons by activation of Akt

The cellular mechanisms underlying the neuroprotective effects of estrogen are only beginning to be elucidated. Here we examined the role of protein kinase B (Akt) activation in 17β-estradiol (E2) inhibition of β-amyloid peptide (31-35) (Aβ31−35)-induced neurotoxicity in cultured rat hippocampal neu