Effect and mechanism of Musashi2 and related signal pathways in genesis and progression of malignant tumor

In mammals, there are two RNA-binding proteins, Musashi (Msi)1 and Msi2, constituting the Msi family. Msi2 is mainly distributed among neural, hematopoietic, gastrointestinal, pancreatic and epithelial stem cells. It is of great importance to maintain the balance between proliferation and differentiation of stem cells and regulate their growth and development. The changed expression of this protein will induce genesis and progression of malignant tumor through many kinds of signal pathways. Thus, Msi2 is trusted to provide a predictive mark and a therapeutic target for related tumors. Key words: Neoplasms; Mechanism; Musashi2