High-Temperature Short-Time Heat Inactivation of HIV and Other Viruses in Human Blood Plasma

An ultra-short-time heating system was used to process blood plasma spiked with various viruses (HIV, vesicular stomatitis virus, encephalomyocarditis virus). Virus reduction and recovery of plasma proteins were measured at various temperatures from 65 to 85 °C. Processing at 77 °C and 0.006 s resulted in a high level of virus kill, including ≥ 4.4 log10 HIV, while maintaining protein structure and activity essentially intact.