Effect of low dose propofol on biological behavior of esophageal squamous cell carcinoma cell line Eca109

AIM:To detect the effect of low dose propofol on the proliferation,apoptosis,migration,and invasion of esophageal squamous cell carcinoma cell line Eca109.METHODS: The proliferation,apoptosis,migration,and invasion of esophageal squamous cell carcinoma cell line Eca109 were detected by MTT assay,flow cytometry,transwell assay respectively.The effect of low dose propofol on expression of heme oxygenase-1(HO-1) was confirmed by Real-time quantitative PCR.RESULTS: Low dose propofol could inhibit the proliferation,migration,invasion and promate the apoptosis of esophageal squamous cell carcinoma cell line Eca109.And low dose propofol increased the expression of HO-1 mRNA in a dose-dependment manner.CONCLUSION: Low dose propofol affects the biological behavior of esophageal squamous cell carcinoma cell line Eca109,which has a relationship with increasing the expression of HO-1.