Development and validation of a combined photoacoustic micro-ultrasound system for in vivo oxygen saturation estimation
2011
Photoacoustic (PA) Imaging can estimate the spatial distribution of oxygen saturation (sO 2 ) and total hemoglobin
concentration (HbT) in blood, and be co-registered with B-Mode ultrasound images of the surrounding anatomy. This
study will focus on the development of a PA imaging mode on a commercially available array based micro-ultrasound
(μUS) system that is capable of creating such images. The system will then be validated in vivo against a complementary
technique for measuring partial pressure of oxygen in blood (pO 2 ). The pO 2 estimates are converted to sO 2 values based
on a standard dissociation curve found in the literature. Finally, the system will be used for assessing oxygenation in a
murine model of ischemia, both during injury and recovery.
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