Preparation and Characterization of Core/Shell-type Ag/Chitosan Nanoparticles with Antibacterial Activity

could enterporous CS nanoparticles synthesized with this method, allowing Ag nanoparticles within chitosannanoparticles were synthesized by reducing silver nitrate with chitosan. Because of the noncovalent interactionbetween CS and EDTA, the EDTA could be easily removed via dialysis against water, and pure core/shell-typeAg/CS nanoparticles could be obtained. The nanoparticles showed higher antibacterial activity toward E. colithan the active precursor Ag nanoparticles and CS.Key Words : Chitosan, Nanocomposite, Antibacterial activityIntroductionChitosan (CS), obtained by extensive deacetylation ofchitin isolated from crustacean shell, is a natural polysac-charide with many useful features such as biocompatibility,biodegradability and antibacterial properties. It, as well as itsderivatives, has great potential applications in such areas asbiotechnology, biomedicine, and food technology.