Diabetes Abolishes Sildenafil-Induced cGMP-Dependent Protein Kinase-I Expression and Cardioprotection

Marina Jamnicki-Abegg,Dorothee Weihrauch,Pascal Chiari,John G. Krolikowski,Paul S. Pagel,David C. Warltier,Judy R. Kersten

Diabetes Abolishes Sildenafil-Induced cGMP-Dependent Protein Kinase-I Expression and Cardioprotection

2007

Marina Jamnicki-Abegg
Dorothee Weihrauch
Pascal Chiari
John G. Krolikowski
Paul S. Pagel
David C. Warltier
Judy R. Kersten

Abstract:The selective phosphodiesterase type 5 inhibitor sildenafil has been demonstrated to produce cardioprotection; however, diabetes is known to abolish cardioprotective signaling. We tested the hypothesis that sildenafil-induced cGMP-dependent protein kinase-I (PKG-I) expression and cardioprot

Keywords:

Cardiology
Protein kinase A
CGMP-Dependent Protein Kinase I
Sildenafil
Myocardial infarction
Diabetes mellitus
Internal medicine
Cardioprotection
cGMP-dependent protein kinase
cGMP-specific phosphodiesterase type 5
Pharmacology
Anesthesia
Medicine

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