가토에서 TGF-β 길항제인 Decorin이 창상치유에 미치는 영향

There have been many trials to decrease the scar formation followed by wound treatment. TGF-β plays a important role on wound healing in adult. Therefore the repression of TGF-β expression will be helpful to decrease scar formation. Decorin is known to competively inhibit TGF-β expression. Decorin were subcutaneously in surgical wounds in rabbits to investigate the preventing effect of scar formation for clinical application. Histologic findings of wound healing progresses is similar with control and experimental group at 2week. 2.5μg decorin of administrated group was similar to those of control group 4 and 8 week. In wound healing process 10 μg decorin of administrated groupsat showed that thickness of immature collagen fibers(scar) was decreased as compared with control group at 4, 8 weeks. 20 μg decorin of administrated group showed similar histologic features to 10 μg administrated group. The wounds of 8week experimental group(10, 20 μg) were completely recovered to the normal surrounding skin tissue including sweat gland and hair follicle. These results suggested that decorin can be of help to the prevention of local scar formation.