The future potential of the Stentrode

The StentrodeTM is a miniaturized neural interface that can record and stimulate the brain from within a blood vessel [1,2]. The StentrodeTM derives its name from the amalgamation of its component parts – stent plus electrode – where the stent is used as a scaffold to support the electrodes (Figure 1). This device has been delivered through the jugular vein and placed adjacent to the brain in the superior sagittal sinus (SSS) without the need for brain surgery. The idea of recording and stimulating the brain from within a blood vessel has existed since 1973 [3]. Improvement over previous attempts for endovascular recording and stimulation came from mounting electrodes on a self-expanding stent allowing it to be anchored in place over long periods of time [3]. Neurovascular stents, such as those of the StentrodeTM, have been used in treating stroke and intracranial hypertension, and have been applied successfully in the clinic for many years with a growing record of safety [4]. The possibility of accessing the brain without brain surgery is appealing and represents a promising outlook for the future of brain-machine interfaces (BMIs) and neuromodulation.