Apixaban (I) in several aqueous co-solvent mixtures: Solubility, solvent effect and preferential solvation

Abstract Equilibrium apixaban (I) solubility in isopropanol (1) + water (2) , ethanol (1) + water (2) , acetone (1) + water (2) and methanol (1) + water (2) mixtures was acquired by a shake-flask method from 288.15 K to 328.15 K under atmospheric pressure of 101.2 kPa. At a certain temperature, the highest apixaban (I) solubility in mole fraction scale was observed in neat solvents of acetone/methanol for the acetone/methanol (1) + water (2) solutions; while for the ethanol/isopropanol (1) + water (2) solutions, the solubility data presented a maximum value with the ethanol/isopropanol mass fraction of about 0.8. The determined solubility values were treated by linear solvation energy relationships in order to explain the solvent effect and find its major descriptors. The preferential solvation was studied by the method of inverse Kirkwood–Buff integrals based on some thermodynamic solution properties. In the methanol (1) + water (2) mixture with compositions 0.31 (1) + water (2) mixture with compositions 0.25 (1) + water (2) mixture with compositions 0.25 (1) + water (2) mixture with compositions 0.20 (1) + water (2) mixture with compositions 0.175