A new method of one-pot synthesis of dicarboxylic acid derivatives and diketones containing quaternary carbon atom and remote functional groups from linear acyl halides

Abstract The one-pot, regioselective synthesis of branched diacid derivatives – diesters, dithioesters, diamides [YC(O)O(CH 2 ) m C(Me) 2 OC(O)Y] and diketones of aromatic and heteroaromatic series, [ArCO(CH 2 ) m C(Me) 2 C(O)Ar,) from available linear acyl halides, C n H 2 n+1 COCl (n = 7–9), CO (1 at) and various nucleophiles (YH = EtOH, CF 3 CH 2 OH, H(CF 2 ) 2 CH 2 OH, thiophene, anisole, Et 2 NH, aniline, and morpholine) in the presence of the superelectrophilic complex, CBr 4 ·2AlBr 3 has been performed for the first time. This method provides access to new and promising groups of dicarboxylic acid derivatives and diketones containing quaternary carbon atom and remote functional groups.