A phase Ib study of NUC-3373 in combination with standard therapies in advanced/metastatic colorectal cancer (NuTide:302).

Andrew L. Coveler,Farasat Kazmi,Kristen Keon Ciombor,Janet Graham,Lisa Jane Rodgers,Michelle Myers,Jordan Berlin,Sarah P. Blagden,T.R. Jeffry Evans

A phase Ib study of NUC-3373 in combination with standard therapies in advanced/metastatic colorectal cancer (NuTide:302).

2021

Andrew L. Coveler
Farasat Kazmi
Kristen Keon Ciombor
Janet Graham
Lisa Jane Rodgers
Michelle Myers
Jordan Berlin
Sarah P. Blagden
T.R. Jeffry Evans

93Background: 5-FU is a key anti-cancer agent used across a broad range of tumors. The anti-cancer metabolite of 5-FU, fluorodeoxyuridine-monophosphate (FUDR-MP), binds and inhibits thymidylate syn...

Keywords:

Medicine
Colorectal cancer
Cancer research
Metabolite
Thymidylate synthase

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