Method for Optimizing Topography-guided Ablation of Highly Aberrated Eyes With the ALLEGRETTO WAVE Excimer Laser

Abstract To evaluate the clinical outcomes of custom topographic neutralizing technique in treating highly aberrated eyes using the WaveLight ALLEGRETTO WAVE Excimer Laser. A retrospective consecutive case series of 67 eyes with decentered ablations and 48 eyes with symptomatic small optical zones after previous LASIK underwent topography-guided retreatment with the ALLEGRETTO WAVE. Sixteen keratoconus eyes underwent topographic neutralizing technique photorefractive keratectomy (PRK). The study assessed preoperative and 6-month and 1-year postoperative results regarding best spectacle-corrected visual acuity (BSCVA), uncorrected visual acuity (UCVA), topography, and predictability. Sixty-seven eyes with previously decentered optical zones had an improvement of centration from 0.92 mm preoperatively to 0.30 mm postoperatively relative to pupil center (P