Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling.
2013
Deletion of Ptpn11 in a newly defined mesenchymal progenitor population in the perichondral groove of Ranvier leads to metachondromatosis by increasing Indian hedgehog expression and activating hedgehog signalling, a process that can be reversed with the use of hedgehog pathway inhibitors.
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