Polyglutamation of methotrexate. Is methotrexate a prodrug

Bruce A. Chabner,Carmen J. Allegra,Gregory A. Curt,N J Clendeninn,Jacob Baram,Shoichi Koizumi,James C. Drake,Jacques Jolivet

Polyglutamation of methotrexate. Is methotrexate a prodrug

1985

Bruce A. Chabner
Carmen J. Allegra
Gregory A. Curt
N J Clendeninn
Jacob Baram
Shoichi Koizumi
James C. Drake
Jacques Jolivet

La polyglutamation est assuree par la folyl polyglutamyl synthetase. Leur etude decrit l'importance pharmacologique de la polyglutamation du methotrexate

Keywords:

Thymidylate synthase
Tetrahydrofolate dehydrogenase
Methotrexate
Prodrug
Medicine
Biochemistry
intestinal mucosa

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