Normal and delayed wound healing is improved by sesamol, an active constituent of Sesamum indicum (L.) in albino rats

Abstract Ethno-pharmacological relevance The seeds of Sesamum indicum Linn. (Pedaliaceae) has been used traditionally for the treatment of wounds in Buldhana district of Maharashtra state. Sesamol is the main anti-oxidative constituent contained mainly in the processed sesame seed oil which has not been explored scientifically for its wound healing activity. Aim of the study To investigate the influence of sesamol (SM) on wound repair, both in normal and dexamethasone (DM) delayed healing processes in albino rats. Materials and methods Incision, excision and dead space wounds were inflicted on albino rats (180–220 g) of either sex, under ketamine anaesthesia. Group I served as control, group II received SM 50 mg/kg i.p., group III was treated with dexamethasone (DM) i.m. (0.17 mg/kg) and SM + DM was given to group IV. The tensile strength, wound contraction, hydroxyproline, lysyl oxidase and total RNA and DNA levels (in granulation tissue) were measured. Results The tensile strength significantly ( p p Conclusion These results indicate that sesamol could be a promising drug in normal as well as delayed wound healing processes.