The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells

The longevity of hematopoietic stem cells requires strict regulation to prevent their exhaustion. Aifantis and colleagues show that the ubiquitin E3 ligase Huwe1 is needed to suppress the activity of the transcription factor N-myc and maintain the quiescence and function of these cells.