Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells

Stefan Rentas,Nicholas Holzapfel,Muluken S. Belew,Gabriel A. Pratt,Veronique Voisin,Brian T. Wilhelm,Gary D. Bader,Gene W. Yeo,Kristin J. Hope

Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells

2016

Stefan Rentas
Nicholas Holzapfel
Muluken S. Belew
Gabriel A. Pratt
Veronique Voisin
Brian T. Wilhelm
Gary D. Bader
Gene W. Yeo
Kristin J. Hope

The RNA-binding protein Musashi-2 increases the self-renewing abilities of human haematopoietic stem cells, which have the potential to be used for regenerative therapies.

Keywords:

Gene Knockdown Techniques
Stem cell
Cell biology
Plasma protein binding
RNA-binding protein
Cell Self Renewal
Immunology
Haematopoiesis
Downregulation and upregulation
Signal transduction
Biology
Transplantation
Progenitor cell
Aryl hydrocarbon receptor
Cord blood
Hedgehog signaling pathway

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