Abstract 13964: Differential ex vivo Stabilization of Transthyretin by AG10 and Tafamidis in Samples From Patients With Moderate or Severely Destabilizing Mutations

Introduction: Transthyretin (TTR) amyloidosis is a progressive, fatal disease caused by destabilizing TTR mutations and age-related factors. Dissociation of tetrameric TTR initiates protein misfold...