One-pot asymmetric synthesis of α-trifluoromethylated amines from α-trifluoromethyl ketones

Abstract Diastereoselective reduction of ( Rs )- N - tert -butanesulfinyl α-trifluoromethyl ketimines formed in situ from the corresponding α-trifluoromethyl ketones and N - tert -butanesulfinamide has been achieved, and either diastereomer of N - tert -butanesulfinyl α-trifluoromethyl amines was obtained in good yields with excellent diastereoselectivities (up to 99:1 dr) using NaBH 4 and L-Selectride as the reductants, respectively.