The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression

Gavin Whissell,Elisa Montagni,Paola Martinelli,Xavier Hernando-Momblona,Marta Sevillano,Peter Jung,Carme Cortina,Alexandre Calon,Anna Abulí,Antoni Castells,Sergi Castellví–Bel,Ana Silvina Nacht,Elena Sancho,Camille Stephan-Otto Attolini,Guillermo P. Vicent,Francisco X. Real,Eduard Batlle

The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression

2014

Gavin Whissell
Elisa Montagni
Paola Martinelli
Xavier Hernando-Momblona
Marta Sevillano
Peter Jung
Carme Cortina
Alexandre Calon
Anna Abulí
Antoni Castells
Sergi Castellví–Bel
Ana Silvina Nacht
Elena Sancho
Camille Stephan-Otto Attolini
Guillermo P. Vicent
Francisco X. Real
Eduard Batlle

Batlle and colleagues explore the mechanisms controlling colorectal cancer initiation. They show that GATA6 promotes adenoma stem cell self-renewal and tumour formation by inhibiting BMP signalling.

Keywords:

Transcription factor
Cell biology
Adenoma
GATA6
Cancer
Colorectal cancer
Stem cell
Colon Adenoma
Cancer stem cell
Biology

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