Conversion of acyclic nonpeptide CCK antagonists into CCK agonists

Abstract The CCK antagonists RP 69758 and ( R )-lorglumide were converted into CCK agonists by the introduction of an N -isopropylanilide agonist “trigger.” The common structural features of these ligands suggest that nonpeptide agonists and antagonists bind to a common site in the CCK receptor.