Effect of cyclodextrin on allergic action of the PiCl-induced in NC/Nga mice

Itching dermatitis, which is very similar to human atopic dermatitis, arises spontaneously in NC/Nga mice. Changes in lesional skin and the plasma concentration of IgE during the development of atopic dermatitis-like disease up to 8 weeks after the start of picryl chloride (PiCl) in NC/Nga mice were examined. In the mice which atopic dermatitis had been induced, 28-day administration of α cyclodextrin (α CD) significantly inhibited aggravation of detmatitis without having effects on body weight. Clinical signs and symptoms seen in PiCl treated NC/Nga mice began with erythema and haemorrhage, following oedema, superficial erosion, deep excoriation, scaling and dryness of the skin. An increase was observed in the number of mast cells and eosinophil infiltration in the lesional skin. Almost human patients with nasal inflammation or bronchial asthmatics symptoms disappeared by oral administration of α CD (5 mg/day) for 2 month. These results suggest that α CD is useful for treatment of human atopic dermatitis.