Aminoheteroaryl compounds substituted pyrazole as protein kinase inhibitors.

A compound of formula 1 ** ** Formula wherein: Y is CR12; A is phenyl substituted by one, two or three R3 groups; R1 is selected from optionally substituted with one, two or three groups R13; R2 is hydrogen; each R3 is independently halogen, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C3-12 cycloalkyl, C6-12 aryl, 3-12 membered heteroalicyclic, 5-12 membered heteroaryl, -S (O) mR4, -SO2NR4R5, -S (O) 2OR4, -NO2, -NR4R5, -CN, -C (O) R4, -OC (O) R4, -O (CR6R7) nR4, -O (CR6R7) (CR6R7) nNR4R5, -O (CR6R7) (CR6R7) n OR 4, -NR 4 C (O) R5, - (CR6R7) nC (O) OR4, - (CR6R7) n OR 4, - (CR6R7) nC (O) NR4R5, -C (= NR6 ) NR4R5, -NR 4 C (O) NR5R6 or -NR 4 S (O) PR5 ;, each R4, R5, R6 and R7 is independently hydrogen, halogen, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, cycloalkyl C3- 12, C6-12 aryl, 3-12 membered heteroalicyclic, 5-12 membered heteroaryl; each R9 is methyl and R10 is hydrogen; R12 is hydrogen; each R13 is independently halogen, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, -S (O) mR4, -SO2NR4R5, - S (O) 2OR4, -NO2, -NR4R5, -CN, -OC ( O) R4, -O (CR6R7) nR4, -NR 4 C (O) R5, - (CR6R7) nC (O) OR4, - (CR6R7) nOR420, - (- C (= NR6) NR4R5, -NR 4 C (O) NR5R6 , -NR 4 S (O) PR5, - (CR6R7) n (3-12 membered heteroalicyclic), - (CR6R7) n (cycloalkyl C3- 12), - (CR6R7) n (C6-12 aryl), - (CR6R7) n (5-12 membered heteroaryl), - (CR6R7) nC (O) NR4R5 or - (CR6R7) nC (O) R4, R13 groups on adjacent atoms may combine to form a C6-12 aryl group, 5- -12 members, C3-12 cycloalkyl or 3-12 membered heteroalicyclic and each hydrogen in R13 is optionally substituted by R3; each m is independently 0, 1 or 2; each n is independently 0, 1, 2, 3 or 4; t is 1, and each p is independently 1 or 2; or a salt, hydrate or pharmaceutically acceptable solvate thereof, with the proviso that the compound is not 3- [1- (2,6-dichloro-3-fluoro- phenyl) -ethoxy] -5- (1H-pyrazol-4-yl) -pyridin-2- ylamine, 3- [1- (2,6-dichloro-3-fluoro-phenyl) -ethoxy] -5- [1- (2-diisopropylamino-ethyl) -1H-pyrazol-4-yl] -pyridine-2- ylamine, 3- [1- (2,6- dichloro-3-fluoro-phenyl) -ethoxy] -5- [1- (2-morpholin-4-ylethyl) -1H-pyrazol-4-yl] - pyridin-2-ylamine or 3- [1- (2,6-dichloro-3-fluoro-phenyl) - ethoxy] -5- (1-methyl-1H-pyrazol-4-yl) -pyridin-2-ylamine.