Селективная адсорбция эндотоксина при уроcепсисе

The influence of selective adsorption of endotoxin on the course of generalized inflammation in the development of urosepsis in 20 cancer patients. Patients were divided into 2 groups – primary and control. The main group consisted of 10 people, the complex of intensive treatment which was supplemented by the provision of extracorporeal hemoperfusion with activated charcoal container with immobilized polymyxin B. Тhe control group included 10 patients who received standard therapy of sepsis. The severity of the condition in patients of main groups according to APACHE II is 24,2±0,9 points, SOFA − 11,9±2, the scores of patients in the control group APACHE II at 23,7±1.5 points, SOFA − 12,7±3,2. The level of activity of endotoxin in the EAA test in the main group reached 0,61±0,12 and control 0,62±0,09. In order to assess the effectiveness of selective adsorption of endotoxin clinical laboratory tests were performed prior to intensive treatment of sepsis (1 phase) and 24 hours after procedure 2 (stage 2 of the study) in patients of the main group and in comparable terms in the control group (72 hours from start of intensive treatment of sepsis). After applying the selective adsorption of endotoxin in the main group ∆SOFA was 5,6±2,1 points in the control group was 2,6±2,2 points (Purosepsis in cancer patients, hemoperfusion with Polymyxin b prevents the progression of sepsis and MOF.