Glioblastoma Multiforme: Role of Cell Cycle-Related Kinase Protein (Method)

Glioblastoma multiforme (GBM), the most severe form of malignant brain tumor, is one of the deadliest cancers identified. Despite multimodal treatments with resection, chemotherapy, and radiotherapy, the prognosis of GBM remains poor over the past 30 years. Thus, the development of new and effective therapies is crucial. In this review, we discuss some alternative strategies for treating GBM by inhibiting the expression of cell cycle-related kinase (CCRK), a protein kinase which has recently been demonstrated to be a candidate oncogene in GBM.