An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

Tilmann Bürckstümmer,Christoph Baumann,Stephan Blüml,Evelyn Dixit,Gerhard Dürnberger,Hannah Jahn,Melanie Planyavsky,Martin Bilban,Jacques Colinge,Keiryn L. Bennett,Giulio Superti-Furga

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

2009

Tilmann Bürckstümmer
Christoph Baumann
Stephan Blüml
Evelyn Dixit
Gerhard Dürnberger
Hannah Jahn
Melanie Planyavsky
Martin Bilban
Jacques Colinge
Keiryn L. Bennett
Giulio Superti-Furga

The identity of the cytoplasmic DNA receptor that activates the inflammasome has remained elusive. Superti-Furga and colleagues use a proteomics screen to identity AIM2 as the DNA sensor for the inflammasome.

Keywords:

Immunology
AIM2
Cell biology
DNA
Biology
Innate immune system
Cytoplasm
Inflammasome
Proteomics
Receptor
IFI16
Cyclic GMP-AMP synthase

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