IFI16

2OQ0, 3B6Y, 3RLN, 3RLO, 3RNU, 4QGU3428623121ENSG00000163565ENSMUSG00000073491Q16666n/aNM_001206567NM_005531NM_001364867NM_001033384NM_001177349NM_001177350NM_001368798NM_001368799NP_001193496NP_005522NP_001351796n/aGamma-interferon-inducible protein Ifi-16 (Ifi-16) also known as interferon-inducible myeloid differentiation transcriptional activator is a protein that in humans is encoded by the IFI16 gene.2oq0: Crystal Structure of the First HIN-200 Domain of Interferon-Inducible Protein 16 Gamma-interferon-inducible protein Ifi-16 (Ifi-16) also known as interferon-inducible myeloid differentiation transcriptional activator is a protein that in humans is encoded by the IFI16 gene. This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53, retinoblastoma-1 and BRCA1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. IFI16 has been shown to play a role in the sensing of intracellular DNA - a hallmark of virally infected cells - and has also been linked to the death of HIV-infected helper CD4 T cells by pyroptosis, a highly inflammatory form of programmed cell death. This article incorporates text from the United States National Library of Medicine, which is in the public domain.