Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine, and Pyronaridine: In Vitro Activity against SARS-CoV-2 and Potential Mechanisms

Ana C. Puhl,Ethan J. Fritch,Thomas J. Lane,Longping V. Tse,Boyd Yount,Carolina Q. Sacramento,Natalia Fintelman-Rodrigues,Tatyana A. Tavella,Fabio T. M. Costa,Stuart Weston,James Logue,Matthew B. Frieman,Lakshmanane Premkumar,Kenneth H. Pearce,Brett L. Hurst,Carolina Horta Andrade,James A. Levi,Nicole J. Johnson,Samantha C. Kisthardt,Frank Scholle,Thiago Moreno L. Souza,Nathaniel J. Moorman,Ralph S. Baric,Peter B. Madrid,Sean Ekins

Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine, and Pyronaridine: In Vitro Activity against SARS-CoV-2 and Potential Mechanisms

2021

Severe acute respiratory coronavirus 2 (SARS-CoV-2) is a newly identified virus that has resulted in over 2.5 million deaths globally and over 116 million cases globally in March, 2021. Small-molec...

Keywords:

severe acute respiratory syndrome coronavirus 2
Coronavirus
In vitro
Virology
Marburg virus
Virus
Repurposing
Pyronaridine
Tilorone
Medicine

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