Pyronaridine is an antimalarial drug. It was first made in 1970 and has been in clinical use in China since the 1980s. Pyronaridine is an antimalarial drug. It was first made in 1970 and has been in clinical use in China since the 1980s. It is one of the components of the artemisinin combination therapy pyronaridine/artesunate (Pyramax). It has also been studied as a potential anticancer drug.