Target Directed Enediyne Prodrugs: hER and AhR Degradation by a Synthetic Oxo-Enediyne.

Abstract An efficient route to oxo-enediynes is presented. A simple oxo-enediyne has been synthesized, which cyclizes to give an isochroman. The agent shows cytotoxicity for ER rich breast cancer cells and a model for its mode of action is proposed.