RAPID COMMUNICATION Proteolytic Processing of Marburg Virus Glycoprotein

), using a vesicular stomatitis virus expressionsystem, have demonstrated that mutations in this domainmodify the ability of EBOV GP to support infectivity.Many viral surface glycoproteins undergo posttransla-tional proteolytic processing. Most of these glycopro-teins are cleaved by subtilisin-like eukaryotic endopro-teases (proprotein convertases) at multibasic cleavagesites (