Significant hemolysis is not required for thrombosis in paroxysmal nocturnal hemoglobinuria

Paroxysmal nocturnal hemoglobinuria (PNH), a rare hematological condition, presents with hemolytic or thrombotic symptoms. PNH stem cells arise due to somatic mutations in the phosphatidylinositol glycan A gene in bone marrow stem cells, resulting in loss of the glycosylphosphatidylinositol anchor