Lymphomatoid papulosis. Ultrastructural study with demonstration of intranuclear and intracytoplasmic viruslike particles.

: Transmission electron microscopic study of the bizarre infiltrating cells from a case of lymphomatoid papulosis reveals intranuclear and intracytoplasmic virus-like particles. These cells have large nuclei with multiple nucleoli, scant to moderate profiles of rough endoplasmic reticulum, mitochondria and a variable number of lysosomes. It is suggested that these abnormal cells are macrophages showing viral cytopathogenic effects.