Lymphomatoid papulosis

Lymphomatoid papulosis (LyP) is a rare skin disorder. The overall prevalence rate of lymphomatoid papulosis is estimated at 1.2 to 1.9 cases per 1,000,000 population. This rare condition has only been studied in depth since 1968.aggressive: Sézary disease Lymphomatoid papulosis (LyP) is a rare skin disorder. The overall prevalence rate of lymphomatoid papulosis is estimated at 1.2 to 1.9 cases per 1,000,000 population. This rare condition has only been studied in depth since 1968. It can appear very similar to anaplastic large cell lymphoma.Type 'A' is CD30 positive, while type 'B' is CD30 negative. It has been described as 'clinically benign but histologically malignant.' It may respond to methotrexate or PUVA. It can evolve into lymphoma.