Biocompatible and Biodegradable Bioplastics Constructed from Chitin via a “Green” Pathway for Bone Repair

Biodegradable plastics are urgently needed in the biomedical field to avoid the secondary surgery for implants after completing the repair of nonload bearing bone defects. Herein, novel chitin based plastics were successfully fabricated by changing the shape and aggregation state structure of chitin hydrogels through drying under a negative pressure, which led to a plastic deformation. The chitin hydrogels were prepared by using an environmentally friendly aqueous NaOH/urea solvent, and then radially oriented under the negative pressure to form chitin bioplastics (CP) on the basis of the removability of the chitin molecular bundles in the hydrogels. Moreover, hydroxyapatite (HAP) was in situ synthesized to obtain the chitin/HAP composite plastics (CHP). Their structure and properties were characterized by SEM, FTIR, 13C NMR, X-ray diffraction and mechanical testing. The results indicated that the bioplastic preparation was a “green” physical process, and the incorporation of HAP reinforced significantly t...