Effect of bevacizumab combined with FOLFOX4 on advanced colorectal cancer.

Aim To observe the effect of FOLFOX4 and FOLFOX4-AVASTIN on metastatic colorectal cancer.Method There 128 colorectal cancer cases with ECOG between 0～2 were be divided into group A(81 cases)and B(47 cases)randomly,and treated with FOLFOX4 and FOLFOX4 plus AVASTIN for 6 courses.Results The overall response rate was 39.5%(complete relieve 1.2%,part relieve 38.3%)in group A and 76.6%(CR14.9%,PR61.7%)in group B.Conclusions The response rate of group B was higher obviously than that of group A and showing significant differences(P0.005).FOLFOX4-AVASTIN may be recommend as the first line regiment for metastatic colorectal cancer.