ДИАГНОСТИЧЕСКОЕ ЗНАЧЕНИЕ ИММУНОЛОГИЧЕСКИХ МАРКЕРОВ АЛЛЕРГИЧЕСКОГО БРОНХОЛЕГОЧНОГО АСПЕРГИЛЛЕЗА У БОЛЬНЫХ БРОНХИАЛЬНОЙ АСТМОЙ

Allergic bronchopulmonary aspergillosis (ABPA) is a severe lung disease caused by hypersensitivity to Aspergillus spp. The search for new diagnostic markers is essential for early detection of the disease in patients at risk and identifying eff ective treatment strategies. 21 patients with ABPA, 37 patients with asthma and 16 healthy subjects were examined. The content of thymic stromal lymphopoietin (TSLP), thymus-associated regulatory chemokine (TARC), IL-8, eosinophil count, total IgE levels and specifi c IgE to Aspergillus fumigatus were determined in serum by ELISA. The positive correlation of the TARC level with the indicators of total IgE, sIgE to Aspergillus fumigatus, the number of eosinophils and the negative correlation relationship with the FEV1 value confi rms the important diagnostic value of this pro-infl ammatory chemokine in patients with ABPA.