The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts

Pratiti Bandopadhayay,Anissa Jabbour,Christopher D. Riffkin,Marika Salmanidis,Lavinia Gordon,Dean Popovski,Lin Rigby,David M. Ashley,David N. Watkins,David M. Thomas,Elizabeth Algar,Paul G. Ekert

The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts

2013

Pratiti Bandopadhayay
Anissa Jabbour
Christopher D. Riffkin
Marika Salmanidis
Lavinia Gordon
Dean Popovski
Lin Rigby
David M. Ashley
David N. Watkins
David M. Thomas
Elizabeth Algar
Paul G. Ekert

Desmoplastic small round cell tumor (DSRCT) is characterized by the presence of a fusion protein EWS/WT1, arising from the t (11;22) (p13;q12) translocation. Here we examine the oncogenic properties of two splice variants of EWS/WT1, EWS/WT1-KTS and EWS/WT1 + KTS.

Keywords:

Cancer research
Pathology
Cell growth
Fusion protein
Stem cell
Cell
Nuclear protein
Wnt signaling pathway
Embryonic stem cell
Desmoplastic small-round-cell tumor
Biology
Cell cycle checkpoint
Mdm2

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