(Malonato)bis[sulfinylbis[methane]-S]platinum(II) compounds: versatile synthons for a new general synthesis of antitumor symmetrical and dissymmetrical (malonato)platinum(II) complexes

New (malonato)platinum(II) compounds, cis-[Pt(OOCACOO)(Me 2 SO) 2 ] (A=CH 2 , cycloalkyl), have been prepared, and their reactions with various amines have led to a new general synthesis of antitumor symmetrical and dissymmetrical (malonato)platinum(II) complexes. Reaction of trans-(―)-1,2-cyclohexanediamine (CHDA) with the cyclobutanedicarboxylate (CBDC) complex cis-[Pt(CBDC)(Me 2 SO) 2 ] has been studied in detail, and crystallographic molecular structure determinations have been carried out on the Pt(CHDA)(Me 2 SO)(CBDC) intermediate and the Pt(CHDA)(CBDC) product