Six plant extracts delay yeast chronological aging through different signaling pathways

// Vicky Lutchman 1 , Pamela Dakik 1 , Melissa McAuley 1 , Berly Cortes 1 , George Ferraye 1 , Leonid Gontmacher 1 , David Graziano 1 , Fatima-Zohra Moukhariq 1 , Eric Simard 2 and Vladimir I. Titorenko 1 1 Department of Biology, Concordia University, Montreal, Quebec, Canada 2 Idunn Technologies Inc., Rosemere, Quebec, Canada Correspondence to: Vladimir I. Titorenko, email: // Keywords : yeast, cellular aging, longevity, plant extracts, aging-delaying chemical compounds, Gerotarget Received : March 04, 2016 Accepted : July 07, 2016 Published : July 18, 2016 Abstract Our recent study has revealed six plant extracts that slow yeast chronological aging more efficiently than any chemical compound yet described. The rate of aging in yeast is controlled by an evolutionarily conserved network of integrated signaling pathways and protein kinases. Here, we assessed how single-gene-deletion mutations eliminating each of these pathways and kinases affect the aging-delaying efficiencies of the six plant extracts. Our findings imply that these extracts slow aging in the following ways: 1) plant extract 4 decreases the efficiency with which the pro-aging TORC1 pathway inhibits the anti-aging SNF1 pathway; 2) plant extract 5 mitigates two different branches of the pro-aging PKA pathway; 3) plant extract 6 coordinates processes that are not assimilated into the network of presently known signaling pathways/protein kinases; 4) plant extract 8 diminishes the inhibitory action of PKA on SNF1; 5) plant extract 12 intensifies the anti-aging protein kinase Rim15; and 6) plant extract 21 inhibits a form of the pro-aging protein kinase Sch9 that is activated by the pro-aging PKH1/2 pathway.