Abstract 13847: Differential Transthyretin Binding, Kinetic Stability and Additive Ex Vivo Stabilization by AG10 Compared to Tafamidis

Introduction: Transthyretin (TTR) amyloidosis is a progressive, fatal disease. Dissociation of tetrameric TTR is the triggering event in the pathogenic mechanism; destabilizing TTR mutations accele...